Assessing prevalence and risk of lung morbidities including lung nodules and cancer using non contrast CT among PLHIV in Pune, India

Primary objective

1. Determine the prevalence of pulmonary nodules, including lung cancer using NCCT.
2. Determine the risk of pulmonary nodules, including lung cancer using NCCT.
3. Evaluate the association of smoking, immune suppression, ART, and TB with the prevalence and risk of NCCT-diagnosed pulmonary nodules (including lung cancer).

Secondary objectives

1. Determine the prevalence and risk of COPD using spirometric volumes among PLHIV, and their association with smoking, immune suppression, ART, and TB.
2. Determine the rate of decline of spirometric volumes and its association with smoking, immune suppression, ART, and TB.
3. Determine the prevalence and risk of ILD using spirometric volumes and NCCT among PLHIV, and their association with smoking, immune suppression, ART, and TB.  
4. Determine the prevalence and risk of PH, using reported clinical symptoms, TTE measurements among PLHIV, and their association with smoking, immune suppression, ART, and TB.
5. Evaluate the rates of change in DLCO and FENO prospectively, and their association with smoking, immune suppression, ART, and TB.

Tertiary objectives

1. Evaluate the association between spirometric volumes and participant reported QOL.
2. Evaluate the association between the fidelity of study implementation and participant loss to follow-up (LTFU).