Tuberculosis in children, adolescents, and women

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Lancet Respiratory Medicine

Since tuberculosis was declared a global emergency in 1993, the introduction of the directly observed treatment short-course (DOTS) and DOTS-Plus strategies has saved millions of lives, but has had little effect on transmission. Tuberculosis remains the leading infectious disease killer on the planet. Of the 7 million new tuberculosis cases notified to WHO in 2018, 58% were men, 34% were women, and 8% were children (aged <15 years). The tuberculosis disease burden in children, adolescents, and women ( appendix ) imposes continuing challenges.

Marais BJ, Amanullah F, Gupta A, Becerra MC, Snow K, Ngadaya E, Sharma M, Hesseling AC, Chakaya M, Zumla A. Tuberculosis in children, adolescents, and women. Lancet Respir Med. 2020 Apr;8(4):335-337. doi: 10.1016/S2213-2600(20)30077-1. Epub 2020 Feb 27. PMID: 32113571.
  • Department of Paediatrics and Child Health, University of Sydney and The Children's Hospital at Westmead, Sydney, NSW 2145, Australia.¬†
  • Pediatric Pulmonology, The Indus Hospital, Karachi, Pakistan.
  • Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA.
  • Centre for International Child Health, Department of Paediatrics, University of Melbourne, Melbourne, Australia.
  • Muhimbili Medical Research Centre, The National Institutes of Medical Research, Dar es Salaam, Tanzania.
  • Department of Communicable Diseases, World Health Organization, South East Asia Regional Office, Delhi, India.
  • Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.
  • Department of Medicine, Therapeutics, Dermatology and Psychiatry, Kenyatta University, Nairobi, Kenya.
  • Department of Infection, Division of Infection and Immunity, University College London, London, UK; NIHR Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, London, UK.