Willingness of Caregivers to Give Preventive Therapy to Children Living in Households of Patients with Rifampin-resistant Tuberculosis

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The International Journal of Tuberculosis and Lung Disease

BACKGROUND Pediatric household contacts (HHCs) of patients with multidrug-resistant TB (MDR-TB) are at high risk of infection and active disease. Evidence of caregiver willingness to give MDR-TB preventive therapy (TPT) to children is limited.

METHODS This was a cross-sectional study of HHCs of patients with MDR-TB to assess caregiver willingness to give TPT to children aged <13 years.

RESULTS Of 743 adult and adolescent HHCs, 299 reported caring for children aged <13 years of age. The median caregiver age was 35 years (IQR 27–48); 75% were women. Among caregivers, 89% were willing to give children MDR TPT. In unadjusted analyses, increased willingness was associated with TB-related knowledge (OR 5.1, 95% CI 2.3–11.3), belief that one can die of MDR-TB (OR 5.2, 95% CI 1.2–23.4), concern for MDR-TB transmission to child (OR 4.5, 95% CI 1.6–12.4), confidence in properly taking TPT (OR 4.5, 95% CI 1.6–12.6), comfort telling family about TPT (OR 5.5, 95% CI 2.1–14.3), and willingness to take TPT oneself (OR 35.1, 95% CI 11.0–112.8).

CONCLUSIONS A high percentage of caregivers living with MDR- or rifampicin-resistant TB patients were willing to give children a hypothetical MDR TPT. These results provide important evidence for the potential uptake of effective MDR TPT when implemented.

Rouzier V, Murrill M, Kim S, Naini L, Shenje J, Mitchell E, Raesi M, Lourens M, Mendoza A, Conradie F, Suryavanshi N, Hughes M, Shah S, Churchyard G, Swindells S, Hesseling A, Gupta A. Caregiver willingness to give TPT to children living with drug-resistant TB patients. Int J Tuberc Lung Dis. 2022 Oct 1;26(10):949-955. doi: 10.5588/ijtld.21.0760. PMID: 36163664; PMCID: PMC9524515.