Archived Research Activities

Studies/Projects

ACTIV-2/A5401: Adaptive Platform Treatment for Outpatients with COVID-19 (Adapt Out COVID)

Post Date:

2021-07-21

Countries:

India

United States

Clinical Sites:

BJGMC

This study was terminated effective 4/18/2022 Rationale: There is an urgent need for a platform to rapidly evaluate therapies in the outpatient setting, to prevent disease progression, and reduce serious complications of COVID-19 and transmission [10]. ACTIV-2/A5401 is a phase II/III randomized,...

COVID-19 Viral Dynamics

Post Date:

2020-12-20

Countries:

United States

This study was terminated effective 9/24/22 Purpose of the study: This study aims to quantitatively define the relationships between (a) testing results obtained via multiple distinct platforms (antigen vs. RT-qPCR), (b) shedding of infectious virus, and (c) self-reported disease symptoms over the...

A Phase 2a, Double-Blind, Placebo-Controlled, Randomized Clinical Trial to Evaluate the Safety and Immunogenicity of ID93 + GLA-SE Vaccine Administered to HIV-Negative Patients at 3 Time Points During Multidrug Therapy for Drug Susceptible Pulmonary TB

Post Date:

2019-10-28

Clinical Sites:

BJGMC

This study was terminated in April 2020. Vidya Mave was PI of this HIV vaccine trial. BACKGOUND: Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (Mtb). TB is one of the leading causes of morbidity and mortality around the world with an estimated 10...

Management of Multidrug-resistant Tuberculosis among ART Programs in Low- and Middle-income Countries within the Global IeDEA Network

Post Date:

2019-07-22

This study was terminated effective: 6/9/2022 Purpose The purpose of the IeDEA MDR-TB survey is to study the clinical management of HIV patients co-infected with MDR-TB or XDR-TB from the perspective of healthcare workers in ART programs participating in the IeDEA global cohort consortium...

Assessing Psychological Distress among Tuberculosis Patients and Their Household Members

Post Date:

2018-07-17

Countries:

India

Clinical Sites:

BJGMC

By assessing psychological distress, Indo-JHU researchers hope to better understand the correlation between depression and TB severity.

Assessing the Feasibility and Acceptability of a Computer-based Avatar-delivered Alcohol Reduction Intervention

Post Date:

2018-07-05

Countries:

India

Clinical Sites:

BJGMC

Study is assessing whether computer-delivered alcohol screening and intervention helps overcome barriers to treatment in India.

Shorter Treatment for Minimal TB in Children (SHINE)

Post Date:

2017-01-17

Countries:

India

Clinical Sites:

BJGMC

This study was terminated effective 5/29/2022 This is a multicountry study being conducted in India, South Africa, Uganda, and Zambia. The principal objective is to determine whether the standard 6 month regimen (8 weeks HRZ(E) followed by 16 weeks HR) can be reduced with similar efficacy, to 4...

Prevalence and Risk Factors for Oral Cancer among HIV-Infected Adults

Post Date:

2016-12-13

Countries:

India

Clinical Sites:

BJGMC

This study was terminated effective 8/26/22 The study is designed as a cross-sectional, single time point study for opportunistic oral cancer screening of HIV-infected and non- HIV adults 21 years or older in an urban hospital. All participants will undergo screening for oral cancer and oral...

Characterization of Findings on Upper Endoscopy in a Public Hospital in Pune, India

Post Date:

2016-07-05

Countries:

India

Clinical Sites:

BJGMC

This study was terminated July 6, 2017. BJMC is the primary facility for non-emergency endoscopies for a large portion of Pune's underserved population. Currently, there is limited data on the endoscopic findings in resource-limited settings, where the population receiving endoscopic evaluation may...

Comparison of Available Purified-protein Derivative (PPD) Tuberculin Skin Test (TST) Antigen Solutions in Detecting Latent Tuberculosis Infection in India

Post Date:

2016-04-21

Countries:

India

Clinical Sites:

BJGMC

NIRT

This study was terminated effective 12/23/2021 This study is conducted by the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH) under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB...

Identifying Strategies to Optimize Prevention, Diagnosis, and Care of Tuberculosis in Health Care Workers of Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospital, Pune, India

Post Date:

2015-10-01

Countries:

India

Clinical Sites:

BJGMC

This study was terminated July 25, 2019. The BJGMC-JHU Fogarty program has identified tuberculosis in health care workers (HCW) as the program's most significant priority. Between June 2011 and December 2013, a total of 47 TB cases were identified among HCW's at the BJGMC...

RePORT: C-TRIUMPH: Substudy on Understanding of Tuberculosis Infection and Preventive Therapy among Skin-Test Positive Household Contacts of Tuberculosis Cases

Post Date:

2015-08-13

Countries:

India

Clinical Sites:

BJGMC

This study was conducted from June 2015–May 2018. It is both relevant and important to gauge awareness of IPT (Isoniazieas an option for preventing TB among those who are tuberculin skin test (TST) positive, given India’s vast TB-infected population pool...

Maternal Inflammation, Diet and Gut Microbiome in HIV: Impact on Infant Outcomes

Post Date:

2015-05-07

Countries:

India

Clinical Sites:

BJGMC

NIRT

This study was conducted from May 2015–May 2018. Led by Dr. Rupak Shivakoti, the primary objective was to determine the feasibility and operational logistics of collecting stool for microbiome analysis, detailed nutritional assessment using a food-frequency...

TBM Kids Substudy: Assessment of Neurocognitive Functions in Children with Tuberculosis Meningitis and Healthy Control Children Using the Mullen Scale of Early Learning Attending a Tertiary Care Public Hospital in Pune, India

Post Date:

2014-09-01

Countries:

India

Clinical Sites:

BJGMC

This study was terminated effective: 2/16/2022 Objectives: The aim of the present study is to examine the neurological deficit in TBM kids and for that we need to assess, feasibility of the MSEL in our set up an Indian population of healthy children and...

Ecobiosocial Approach for Dengue Vector Control

Post Date:

2013-09-15

Countries:

Colombia

Dengue is a major public health concern in the Region of the Americas. Working in a dengue endemic area of Colombia, the Centro de Estudios e Investigación en Salud (CEIS) Fundación Santa Fe de Bogotá conducted a multisite study focused on improved dengue prevention. CCGHE and Fundacion Santa Fe d...

Perceptions and Acceptability of mHealth Interventions: A Mixed Methods Study Using emocha®

Post Date:

2013-09-14

Countries:

Uganda

This comprehensive formative research study was designed to help guide the development and implementation of novel, task-shifting mHealth HIV/AIDS care interventions at a community-based HIV/AIDS clinic in Kampala, Uganda. Using emocha®, important knowledge was gained on acceptability and...

Hair Concentrations of Anti-tuberculosis Drugs Among HIV-infected and Uninfected Children in India

Post Date:

2013-05-07

Countries:

India

Clinical Sites:

BJGMC

NIRT

This study was terminated May 15, 2017. In the developing world, tuberculosis (TB) is a major cause of mortality among HIV-infected children, a population where measuring treatment adherence and drug levels is difficult. We propose an innovative therapeutic...

ACTG 5279: Phase III Clinical Trial of Ultra-Short-Course Rifapentine/Isoniazid for the Prevention of Active Tuberculosis in HIV-Infected Individuals with Latent Tuberculosis Infection

Post Date:

2012-07-23

Countries:

India

Clinical Sites:

BJGMC

This study was terminated April 27, 2015. Dr. Amita Gupta is Protocol Co-Vice Chair for this multinational clinical trial being conducted in Botswana, Brazil, Haiti, Kenya, Malawi, Peru, Puerto Rico, South Africa, Tanzania, Thailand, Uganda, United States, Zambia, Zimbabwe, and India by the...

A5274: Reducing Early Mortality and Early Morbidity by Empiric Tuberculosis Treatment Regimens

Post Date:

2011-10-01

Countries:

India

Clinical Sites:

BJGMC

This study was terminated in May 2017. Dr. Amita Gupta is Protocol Co-Vice Chair for this multinational clinical trial being conducted in Brazil, Haiti, Kenya, Malawi, Peru, South Africa, Uganda, Zambia, and Zimbabwe , and in India by the Baltimore-Washington-India Clinical...

Characterization of Pulmonary and Extrapulmonary Tuberculosis Among Adult Patients Admitted to Sassoon General Hospital, Pune, India

Post Date:

2011-09-27

Countries:

India

Clinical Sites:

BJGMC

This study was terminated September 21, 2012. The diagnosis of pulmonary and extrapulmonary tuberculosis is usually made clinically. While confirmation from laboratory tests is sought, the sensitivity of such diagnostic tests is poor. TB diagnostics are still evolving and in resource poor settings...

Archived Research Activities

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